Brain development, brain functioning, growth and metabolic aspects in the clinical management of transsexual adolescents.
Recruiting
- Conditions
- Transsexuality according to the DSM IV criteria.
- Registration Number
- NL-OMON26605
- Lead Sponsor
- VU university medical center
- Brief Summary
Delemarre-van de Waal HA, Cohen-Kettenis PT. Clinical management of gender identity disorder in adolescents: a protocol on psychological and paediatric endocrinology aspects.Eur J Endocrinol. 2006 Nov;155 Suppl 1:S131-7.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 264
Inclusion Criteria
Inclusion criteria pubertal patients:
1. Girls and boys with transsexualism who are eligible for sex reassignment according to psychologist and psychiatrist (If they are older than 12 years, psychologically stable and live in a stable social environment);
Exclusion Criteria
Exclusion criteria patients:
1. Intersex conditions;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Cognition: performance and reaction time on three cognition tasks (verbal fluency task, mental rotation task and emotional faces task), reaction times and performance will be measured;<br /><br>2. Functional MRI: data during the verbal fluency task, mental rotation task and emotional faces task;<br /><br>3. Structural MRI: data on total brain volume, gray and white matter (amount and percentage), CSF, volume frontal and temporal lobe, gyrification, brain asymmetry. ROI analysis of basal ganglia, amygdala, hippocampus, corpus callosum, hypothalamus.
- Secondary Outcome Measures
Name Time Method 1. Score from -10 to 10 on handedness questionairre;<br /><br>2. Performance score on adapted WISC-III questionairre (4 items: 2 performance, 2 verbal);<br /><br>3. Information about psychological functioning (parent questionairre);<br /><br>4. Anthropometric data, information about pubertal stage according to Tanner;<br /><br>5. Information about homosexuality/ transsexuality in familymembers;<br /><br>6. Digital photographs and physical appearance list (14 items).