Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Phase 4

Completed

• Conditions: Anaesthesia
• Interventions: Drug: Propofol; Drug: desflurane

• Registration Number: NCT00446212
• Lead Sponsor: Melbourne Health

Brief Summary

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Detailed Description

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Study Timeline

• Study Start: 2006-08
• Study First Submitted: 2007-03-08
• Study First Submitted QC: 2007-03-08
• Study First Posted: 2007-03-12
• Primary Completion: 2008-07
• Study Completion: 2008-07
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-28
• Last Update Posted: 2013-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Male and female patients
• Age between 18 and 50 years
• Presenting for elective surgery under general anaesthesia

Exclusion Criteria

• Inadequate English language comprehension
• Major drug abuse problem

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Propofol	Propofol based anaesthetic maintenance with propofol effect-site steered target-controlled infusion, in addition to fentanyl and non-opioid analgesics
2	desflurane	Desflurane based anaesthetic maintenance with manually controlled administration in 100% oxygen in addition to fentanyl and non-opioid analgesics

Primary Outcome Measures

Name	Time	Method
Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire	recovery room stay

Trial Locations

Locations (4)

Royal Perth Hospital; 🇦🇺 Perth, Western Australia, Australia

Waikato Hospital; 🇳🇿 Hamilton, New Zealand

Royal Melbourne Hospital; 🇦🇺 Parkville, Victoria, Australia

King Edward Memorial Hospital for Women; 🇦🇺 Subiaco, Western Australia, Australia