The influence of different surgical interventions on neural food cue reactivity in obese patients

• Conditions: E66; Obesity

• Registration Number: DRKS00019850
• Lead Sponsor: Zentralinstitut für Seelische Gesundheit Mannheim

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-11-26
• Study Start: 2019-11-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

For all study participants
- age between 18 and 65 years,
- the capacity to give informed consent and to handle the questionnaires
- written informed consent

For patients:
- BMI (kg/m2) > 35 (= grade 2 obesity) according to the ICD-10
- waist circumference < 160 cm (limited by scanner diameter)

Exclusion Criteria

-withdrawal of informed consent
- history or current diagnosis of any psychiatric disorder, (with the exception of nicotine addiction) that needed to be treated pharmacologically in the last 12 months
- current cognitive behavioral therapy
- current use of illicit drugs
- current suicidal ideation
- history of brain injury or severe neurological disorder
- current instable somatic disorder
- current intake (last 4 months) of any centrally acting psychoactive or anti-obesity medications (i.e. sedatives, antipsychotics, including long-acting injectable antipsychotics, antidepressants, opioid analgesics as well as DPP (dipeptidyl peptidose IV) inhibitors and GLP (Glucagon-like peptide)-1 antagonists,
- all participants with a history of surgical interventions in the gastrointestinal system
-all participants requiring permanent medical monitoring or requiring medical interventions during the study period
- contraindications to fMRI scanning (e.g. metal implants),
- pregnant or breast-feeding females

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Our study was aimed at detecting alterations of mesolimbic response to food-associated visual cues, both 8 as well as 24 weeks after bariatric surgery (first arm: Roux en Y bypass, second arm sleeve gastrectomy)

Secondary Outcome Measures

Name	Time	Method
In addition, our study was aimed at identifying alterations of appetite regulating hormones both 8 as well as 24 weeks after bariatric surgery (first arm: Roux en Y bypass, second arm sleeve gastrectomy).