Pilot study to determine calprotectin and aMMP-8 concentrations in sulcus fluid in patients >= 65 years of age.
- Conditions
- K05.3K05.1Chronic gingivitisChronic periodontitis
- Registration Number
- DRKS00027385
- Lead Sponsor
- Poliklinik für Zahnerhaltung und Parodontologie, Zentrum für Zahn- Mund und Kieferheilkunde, Uniklinik Köln
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting withdrawn before recruiting started
- Sex
- All
- Target Recruitment
- 30
Inclusion criteria are age >= 65 years and written informed consent, in treatment at the Polyclinic of Dental Preservation and Periodontology.
Exclusion criteria are active tumor disease requiring treatment, infection requiring treatment, current antibiotic treatment, chronic inflammatory disease such as rheumatoid arthritis, inflammatory bowel disease, osteomyelitis, or previous (within 2 weeks) apoplectic insult with lysis treatment; GFR <30 ml / min, dialysis requirement, coronary artery disease requiring intervention, non-plaque induced gingivitis. These diseases lead to altered sulclus fluid levels of calprotectin and aMMP-8 in the presence of high inflammatory markers and should therefore be excluded from inclusion.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method During the clinical implementation of the study protocol (DRKS ID: DRKS00024446), which has already received a positive decision, it was noticed in the study population included there (geriatric patients) that the resulting aMMP-8 and calprotectin values were significantly outside the expected reference values. After consultation with the laboratory, the question arose whether this is a) due to the fact that the study protocol cannot be optimally performed in outreach care or b) the reference values are not applicable for this population. Therefore, the pilot study presented here will first clarify whether the test procedure depicts valid results for patients of the same age with the corresponding gum diseases in order to then be able to further conduct study 20-1721 or to put its results into a concrete overall context.<br>Study parameters:<br>- Age and gender <br>- Clinical oral findings in the context of heal care<br>- Calprotectin and aMMP-8 concentrations of the sulcus fluid
- Secondary Outcome Measures
Name Time Method The aim of this pilot study is to investigate calprotectin and aMMP8 levels in the sulcular fluid of patients with clinically diagnosed gingivitis and periodontitis. These levels will be compared to those of patients with gingival and periodontal health.