ATURAL KILLER CELL RECEPTOR VARIABILITY DURING THE MENSTRUAL CYCLE

Completed

• Conditions: Menstrual cycle; 10021460; 10013326

• Registration Number: NL-OMON50034
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Healthy women between the age of 18 and 36 with no chronic medical conditions,
like chronic hypertension, chronic kidney failure, chronic immune conditions
(SLE) or chronic medication use, with a natural menstrual cycle, defined by no
contraceptive use and healthy women with a copper spiral
Healthy men between the age of 18 and 36 with no chronic medical conditions,
like chronic hypertension, chronic kidney failure, chronic immune conditions
(SLE) or chronic medication use

Exclusion Criteria

- Current or recent (<2 weeks) symptomatic infection
- Previous pregnancy with complications, such as repeated miscarriages,
preeclampsia, or diabetes gravidarum
- Unable to give mentally capable consent in Dutch

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Percentage of NK cells with activating and inhibitory receptors in peripheral<br /><br>blood. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Percentage of NK cells with activating and inhibitory receptors in menstrual<br /><br>blood.<br /><br>Percentage of degranulation of NK cells in peripheral blood.<br /><br>Percentage of degranulation of NK cells in menstrual blood. </p><br>