Analgesic Effect of Pulmonary Recruitment and Intraperitoneal Hydrocortisone in Laparoscopic Gynecological Surgery
- Conditions
- Laparoscopic Gynecological Surgery
- Interventions
- Combination Product: Pulmonary Recruitment Maneuver
- Registration Number
- NCT03845608
- Lead Sponsor
- Cairo University
- Brief Summary
The aim of this study is to compare the postoperative analgesic efficacy of intraperitoneal hydrocortisone to pulmonary recruitment maneuver in Laparoscopic gynaecological surgery.
- Detailed Description
Laparoscopic surgeries are becoming more attractive because of an early recovery . However, post laparoscopic shoulder and upper abdominal pain may cause more discomfort to the patient than the pain at the incision site.
Proper pain relief is a major concern and area of focus. Pre-operatively, one of the most common questions asked by patients about the amount of pain they will experience after the surgery. Pain has been found to be one of the three most common medical causes of delayed discharge after ambulatory surgery, the other two being drowsiness and nausea and vomiting. Unfortunately prevention and treatment of postoperative pain continues to be a major challenge in postoperative care.
Good pain control after surgery is important to prevent negative outcomes such as tachycardia, hypertension, myocardial ischemia, decrease in alveolar ventilation, and poor wound healing.
Pain also can prolong hospital stay, which is particularly important in day case procedures.
The mechanism of laparoscopy induced shoulder pain is mainly derived from carbon dioxide retention within the abdomen, subsequently irritating the phrenic nerve and causing referred pain in the C4 dermatome. Moreover, carbon dioxide trapped between the liver and the right diaphragm, irritating the diaphragm, also causes upper abdominal pain.
Although there are many analgesic drugs available for postoperative pain, many patients still find them to be suboptimal for controlling pain.
Many strategies, including treatment with non steroidal anti-inflammatory drugs, have been used to try to reduce laparoscopy-induced shoulder pain however, no sufficiently reliable methods have been reported yet .
Also Intraperitoneal local anesthetic was tried as an important addition for postoperative pain in the era of modern surgery. The method of delivering local anesthetic directly to the intraperitoneal cavity was first described in 1951 by Griffin et al. ; however, this method was forgotten for many years until its implementation in minimal access surgery was reappeared. It significantly reduces postoperative pain and opioid consumption after laparoscopic gynecological and general surgical operations.
Another effective method is the pulmonary recruitment maneuver (PRM) which can mechanically remove residual carbon dioxide and therefore decreasing peritoneal irritation, and shoulder pain.
Intravenous steroids have been used successfully for postoperative pain relief in different kinds of surgery . Also intraperitoneal hydrocortisone was has been used effectively to reduce pain after laparoscopic cholecystectomy.
In addition combination of intraperitoneal local anesthetics with hydrocortisone was proved to be a successful method in controlling upper abdominal and shoulder pain after laparoscopic procedures.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 45
-
• female gender, age 20-45 years undergoing laparoscopic gynecological operations
- American Society of Anesthesiologist physical status classification of I or II
-
• Patients younger than 20 years or older than 45 years
- History of chronic pain
- Regular medication with analgesics, or steroids
- Analgesic use within 24 h of surgery ,drug or alcohol abuse
- Associated chronic diseases like diabetes mellitus, pulmonary diseases ,poor cardiac reserve,hepatorenal insufficiency.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Pulmonary Recruitment Maneuver Pulmonary Recruitment Maneuver Pulmonary recruitment maneuver will be performed manually using positive-pressure ventilation to inflate the lungs and lower the diaphragm, which can increase intraperitoneal pressure mechanically and remove residual carbon dioxide from the peritoneal cavity Intraperitoneal Hydrocortisone Pulmonary Recruitment Maneuver Drug Injection: 100mg of Hydrocortisone will be injected In the peritoneum
- Primary Outcome Measures
Name Time Method The first 24 hours total analgesic consumption. 24 hours after surgery Total amount of opioid drugs used after surgery for assessment of post operative pain
- Secondary Outcome Measures
Name Time Method Length of the recovery and hospital stay (hours) 24 hours postoperative Duration between end of operation and patient discharge from hospital
Incidence of postoperative nausea ,vomiting or abdominal distension(%) 24 hours postoperative gastrointestinal complications after surgery