Fasted Exercise in People With Type 1 Diabetes

Not Applicable

Completed

• Conditions: Type1diabetes
• Interventions: Behavioral: Effects of the type of exercise on blood glucose concentrations

• Registration Number: NCT03544684
• Lead Sponsor: Liverpool John Moores University

Brief Summary

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Detailed Description

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period. Fourteen people with type 1 diabetes (duration of type 1 diabetes 8.2±1.4 years), all on basal-bolus regimen, completed a randomised, counterbalanced, crossover study. Continuous glucose monitoring was used to assess glycaemic control following a single bout of HIT (6 x 1min intervals) and 30 mins of moderate-intensity continuous training (MICT) on separate days, compared to a non-exercise control day (CON). Exercise was undertaken following an overnight fast with omission of short-acting insulin. Capillary blood glucose samples were recorded pre and post-exercise to assess the acute changes in glycaemia during HIT and MICT.

Study Timeline

• Study Start: 2015-03-09
• Primary Completion: 2017-10-10
• Study Completion: 2017-10-10
• Study First Submitted: 2018-05-09
• Study First Submitted QC: 2018-05-21
• Status Verified: 2018-06
• Study First Posted: 2018-06-04
• Last Update Submitted: 2018-06-07
• Last Update Posted: 2018-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• duration of type 1 diabetes >6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history

Exclusion Criteria

• duration of type 1 diabetes <6 months,
• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI >30 kg∙m-2)
• pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg)
• angina
• autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative and
• unstable proliferative retinopathy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High intensity interval training (HIT)	Effects of the type of exercise on blood glucose concentrations	glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of high-intensity interval training (HIT) in the morning under fasted conditions
Control day with no exercise	Effects of the type of exercise on blood glucose concentrations	glycaemic profile will be assessed using continuous glucose monitors following a single 24-hour period in which participants performed no exercise
moderate intensity continuous training (MICT)	Effects of the type of exercise on blood glucose concentrations	glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of moderate-intensity continuous training (MICT) in the morning under fasted conditions

Primary Outcome Measures

Name	Time	Method
24 hour glycaemic profile	24 hours	Continuous glucose monitoring will be used to assess the effects of an acute bout of fasted high intensity interval training or moderate intensity continuous training on 24 hour glycaemic profile.

Trial Locations

Locations (1)

Liverpool John Moores University; 🇬🇧 Liverpool, Merseyside, United Kingdom