Fasted Exercise in People With Type 1 Diabetes

Not Applicable

Completed

• Conditions: Type1diabetes

• Registration Number: NCT03544684
• Lead Sponsor: Liverpool John Moores University

Brief Summary

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Detailed Description

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period. Fourteen people with type 1 diabetes (duration of type 1 diabetes 8.2±1.4 years), all on basal-bolus regimen, completed a randomised, counterbalanced, crossover study. Continuous glucose monitoring was used to assess glycaemic control following a single bout of HIT (6 x 1min intervals) and 30 mins of moderate-intensity continuous training (MICT) on separate days, compared to a non-exercise control day (CON). Exercise was undertaken following an overnight fast with omission of short-acting insulin. Capillary blood glucose samples were recorded pre and post-exercise to assess the acute changes in glycaemia during HIT and MICT.

Study Timeline

• Study Start: 2015-03-09
• Primary Completion: 2017-10-10
• Study Completion: 2017-10-10
• Study First Submitted: 2018-05-09
• Study First Submitted QC: 2018-05-21
• Status Verified: 2018-06
• Study First Posted: 2018-06-04
• Last Update Submitted: 2018-06-07
• Last Update Posted: 2018-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• duration of type 1 diabetes >6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history

Exclusion Criteria

• duration of type 1 diabetes <6 months,
• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI >30 kg∙m-2)
• pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg)
• angina
• autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative and
• unstable proliferative retinopathy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
24 hour glycaemic profile	24 hours	Continuous glucose monitoring will be used to assess the effects of an acute bout of fasted high intensity interval training or moderate intensity continuous training on 24 hour glycaemic profile.

Trial Locations

Locations (1)

Liverpool John Moores University; 🇬🇧 Liverpool, Merseyside, United Kingdom