Evaluation of dynamic MRI with T1-maps correlated with histopathology in patients with Crohn's Disease

Completed

• Conditions: Crohn's disease; inflammatory bowel disease; 10017969

• Registration Number: NL-OMON32582
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Crohn's Disease
Scheduled for elective surgery of the small bowel
> 18 years old

Exclusion Criteria

general contraindications for MRI (pacemaker, pregnancy, renal insuffiency, claustrophobia)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter will be the accuracy of detecting disease activity and<br /><br>efficacy of DCE MRI with T1 mapping and DWI at MR in patients with proven<br /><br>Crohn*s disease as compared to histopathology.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. To determine the correlation between Gadolinium concentration of the<br /><br>pathological bowel wall and histopathological activity.<br /><br>2. To determine the correlation between enhancement curves at DCE-MRI and CDAI,<br /><br>CRP.<br /><br>3. To determine the correlation between Gadolinium concentration of the<br /><br>pathological bowel wall and CDAI, CRP.<br /><br>4. To determine the correlation between histopathology and enhancement patterns<br /><br>of the colonic wall.<br /><br>5. To determine the correlation between histopathology and DWI.</p><br>