Evaluation of tumor variability with MRI before and during radiotherapy treatment in patients with an orpharyngeal or oral cavity carcinoma

Completed

• Conditions: oropharyngeal/oral cavity cancer; throat cancer; 10017991

• Registration Number: NL-OMON41260
• Lead Sponsor: Antoni van Leeuwenhoek Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Histology proven squameus carcinoma of oropharynx or oral cavity
- Bulky T2-4, Nx, M0
- Planned for curative radio-chemotherapy

Exclusion Criteria

Contra indication for MRI

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Analyses:<br /><br>Rigid match of MRI and CT/CBCT:<br /><br>- Drawing of GTV volume on MRI and CT<br /><br>- Mapping of marker position on CT and daily CBCTs<br /><br>- Evaluation of volume changes preRT MRI compared to MRI in week 3<br /><br>- Evaluation of marker position compared to MRI volume<br /><br>- Evaluation of daily marker position on CBCT<br /><br>- Comparing of organs at risk on CT, CBCT and MRI<br /><br>- Evaluation of interobserver variation of three delineators<br /><br>- Analysis of dosimetric consequences of volume changes during radiotherapy<br /><br>- Analysis of Ktrans en Vp of the 3 MRI scans performed before the start of<br /><br>treatment</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Niet van toepassing</p><br>