Modulation of the Intestinal Microbiome, and Its Effects on Endurance Exercise Capacity in Moderately Trained Individuals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Microtia
- Sponsor
- Maastricht University
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Time to Exhaustion
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
Detailed Description
The study conforms to a randomized, single-blinded, placebo-controlled parallel study design. a prebiotic supplement will be selected based on a participants gut microbiota. 1 sachet of prebiotic or placebo will be given twice a day over a period of 6 weeks. Before the start of the study, a VO2max test will be performed. Subjects will bring faecal samples which is collected at home. A time to exhaustion of approximately 80% of their VO2max will be performed at baseline and after the 6 weeks intervention period.
Investigators
Fred Troost
Principal Investigator
Maastricht University
Eligibility Criteria
Inclusion Criteria
- •Male or female 18 - 40 y
- •BMI range 18.5 - 25 kg/m2
- •Recreational active (performing non-competitive physical endurance exercise at least two times per week with a minimum duration of 60 minutes per exercise bout)
Exclusion Criteria
- •Performing regular resistance training (3+ times per week, carrying out progressive overload training)
- •Subject following an overly imbalanced or restrictive diet as per nutritional advice
- •Participants who received antibiotics in the 90 days prior to the start of the study
- •Self-admitted lactose intolerance
- •Administration of probiotic or prebiotic supplements in the 14 days prior to the study
Outcomes
Primary Outcomes
Time to Exhaustion
Time Frame: From baseline to end of the study (up to max 45 days)
Time on cycle ergometer until exhaustion
Secondary Outcomes
- Insulin(From baseline to end of the study (up to max 45 days))
- Plasma short chain fatty acids(From baseline to end of the study (up to max 45 days))
- Gut microbiota composition(From baseline to end of the study (up to max 45 days))
- Blood glucose(From baseline to end of the study (up to max 45 days))
- Intestinal permeability by sugar test(From baseline to end of the study (up to max 45 days))