eural development of spatial cognition: an fMRI study on the effects of current and past nutritional status

Recruiting

Conditions: gezonde proefpersonen, eventueel met overgewicht
not applicable

Registration Number: NL-OMON44559

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 52

Inclusion Criteria

Age: 8-10
Healthy
fMRI compatible
Proficient use of Dutch in both child and parent

Exclusion Criteria

- Deafness, blindness, or sensori-motor handicaps
- Neuropsychiatric disorders
- Diabetes
- Chronic inflammatory diseases
- Daily use of ibuprofen, aspirin or glucocorticoids
- Any recent tooth extraction one month prior to the experiment
- History of oral candidiasis
- Acute illness with fever, vomiting, or diarrhea within 5 days of the study
- Recent use of antibiotics (within 3 months prior to the experiment);Exclusion criteria for MRI:
- Non-removable metal in the upper body
- Active implant, pacemaker, neurostimulator, insulin pump and/or auditory prosthetic
- Epilepsy
- Claustrophobia
- Brain surgery in the anamnesis

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in brain activation patterns (fMRI) pre- and post-training are the<br /><br>main outcome measures for this study. These will be related to nutritional<br /><br>status, as measured by a composite score of the Dutch healthy diet index (i.e.<br /><br>a food frequency questionnaire assessing adherence to the Dutch healthy diet<br /><br>guidelines) and visceral adipose tissue quantified by abdominal MRI. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In secondary analyses, we want to see how inflammatory markers, DNA methylation<br /><br>(LY86 gene) (both measured from saliva) and gut microbiome diversity (measured<br /><br>from stool) relate to the neurocognitive development of spatial cognition, as<br /><br>potential mediators of the primary effects.<br /><br>We will also decompose the composite score based on the FFQ and visceral<br /><br>adipose tissue to explore whether sub-components are driving the effects.<br /><br>As motivation for food reward and executive functioning have been clearly<br /><br>related to obesity in previous studies with children, we will include<br /><br>behavioural measures of these as a positive control (using the Progressive<br /><br>Ratio task and Flanker task respectively). </p><br>