ACTRN12610000219088终止4 期
The effects of metformin on the LKB1/AMP-activated protein kinase (AMPK) pathway in breast tissue from women scheduled for reduction mammoplasty, a pilot study
适应症
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 38 Years 至 60 Years（—）
- 性别
- Female
入选标准
- •a) who are aged between 38 and 60 years
- •b) who are attending a breast surgeon and are scheduled to have a reduction mammoplasty
- •c) who have provided informed consent
排除标准
- •1. Women with any of the following:
- •a) Use of any systemic hormones in the last 6 months;
- •b) serious endocrine disorder with systemic disease;
- •c) alcohol consumption greater than 3 standard drinks per day;
- •d) known acute or chronic liver disease;
- •e) cardiac failure requiring medication
- •f) known renal disease
- •g) chronic hypoxic lung disease
- •e) type 2 or insulin dependent diabetes mellitus or use of an oral hypoglycemic agent.
- •2. Women who, in the opinion of the investigator, are a poor medical or psychiatric risk for treatment in a research protocol.
- •3. Women who have participated in a medical or surgical research protocol in the preceding 28 days.
研究者
相似试验
进行中（未招募）
1 期
The effect of metformin on biomarker activity in primary breast cancer - NeoMet TrialEUCTR2007-000306-70-GBniversity of Dundee55
进行中（未招募）
1 期
The inhibitory effect of metformin on gluconeogenesis in relation to polymorphisms in Organic Cation Transporter 1 (OCT1) in healthy volunteersHealthy volunteers (diabetes mellitus 2)MedDRA version: 14.1Level: LLTClassification code 10045242Term: Type II diabetes mellitusSystem Organ Class: 10027433 - Metabolism and nutrition disordersEUCTR2011-001696-39-DKniversity of Southern Denmark, Clinical Pharmacology
已完成
2 期
Effect of metformin on the expression of non-coding long-term RNA in diabetic patients.Diabetes mellitus type II in people New case.Diabetes mellitus due to underlying conditionIRCT20190303042903N1Yasouj University of Medical Sciences35
已完成
不适用
Elucidation of a novel mechanism of metformin action through the gastrointestinal tractJPRN-UMIN000039517Kobe University
招募中
2 期
The effect of Metformin on complication of strokesStroke.Stroke, not specified as haemorrhage or infarctionIRCT20160318027097N5Vice Chancellor for research of Ardebil University of Medical Sciences100