Role of various factors in Dengue disease severity
Not Applicable
- Conditions
- Health Condition 1: A90- Dengue fever [classical dengue]
- Registration Number
- CTRI/2019/05/019028
- Lead Sponsor
- Manipal Institute of Virology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Acute febrile illness (AFI) cases (within 72 hrs of onset of fever) with any other symptoms suggestive of dengue fever, like headache, bodyache, retro-orbital pain, nausea/vomiting, petechiae/ecchymoses/purpura, bleeding gums, rash, abdominal pain, lethargy/restlessness, admitted in ICUs as well as wards at KMC, Manipal
Exclusion Criteria
Not willing to provide informed consent and without a legally authorized representative available
Immuno-compromised cases like HIV+ve (with CD4 count < 350/mm3), patients on chemotherapy or steroids or immunosuppressive drugs in last one year, post-transplant recipients
Known cases of Liver cirrhosis
Mixed infections (malaria, influenza, chikungunya, scrub typhus, leptospirosis, etc.)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Insight into association of DENV NS1 antigenemia & viremia with disease severity <br/ ><br>â?¢Effect of serotype-specific DENV NS1 on capillary permeability in mouse model <br/ ><br> <br/ ><br>Timepoint: one year, two year, three year
- Secondary Outcome Measures
Name Time Method Role of DENV NS1-anti NS1 immune complex formation in disease pathogenesis and its association with disease severityTimepoint: one year <br/ ><br>two years <br/ ><br>three years