Comparison of the retinal thickness and retinal nerve fibre layer thickness using HD-OCT between treated and untreated children with anisometropic or strabismic amblyopia in comparison to healthy eyes.
- Conditions
- Amblyopia10047518
- Registration Number
- NL-OMON42678
- Lead Sponsor
- Canisius Wilhelmina Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 360
In order to be eligible to participate in this study, a patient must meet the following criteria:;Children cooperative for OCT examination.
The refraction error must be within the range of -20 to +20 diopters due to limitations of the OCT device.;Untreated strabismic and anisometropic amblyopes:
Within the age range of three to six years.
With at least a two line visual acuity difference between the amblyopic and the fellow eye.
Teated strabismic and anisometropic amblyopes:
Within the age range of seven to twelve years.
With equal (1.0 snellen) or nearly equal visual acuity, no more than one line difference.
With at least a two line visual acuity difference between the amblyopic and the fellow eye before treatment.
Treated as well as untreated anisometropic amblyopes need to have a difference in refraction error of at least 1 diopter spherical and/or 1 diopter astigmatic difference. ;Age matched controls:
Are orthotropic or have a slight phoria on cover testing with quick recovery
Have a similar refraction error, spherical and/or astigmatism of no more than 0,75 diopters.
- Patients with a systemic disease or ophthalmic disease.
- Infants born at <32 weeks post conception.
- Infants with ROP.
- Patients with nystagmus or eccentric fixation.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method