NCT00226018
Completed
Phase 4
Performance of Acceleromyography With and Without Preload During Neuromuscular Blockade
ConditionsNeuromuscular Blockade
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Neuromuscular Blockade
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- The precision of acceleromyography with and without preload during recovery
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
The purpose of this study is to examine the precision, bias and limits of agreement when monitoring the neuromuscular block with acceleromyography with and without preload and compare the method to the gold standard, mechanomyography.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA I-III
- •General anesthesia \> 1 hour
- •Surgery under supine position with possibility of monitoring the neuromuscular block in both arms (thumbs)
- •Written informed content
Exclusion Criteria
- •Neuromuscular disorders, hepatic and renal dysfunction
- •Medication expected to interfere with the neuromuscular blocking agent
- •Allergy to any medication used during anesthesia
- •Body weight less or exceeding 20% of the ideal body weight
- •Pregnancy or breastfeeding
Outcomes
Primary Outcomes
The precision of acceleromyography with and without preload during recovery
Secondary Outcomes
- Bias and limits of agreement for acceleromyography (AMG) with and without preload compared to mechanomyography (MMG) during recovery
- All the following outcomes obtained with AMG with and without preload are compared to MMG. Furthermore the responses are compared when the AMG-values are "normalized":
- Bias og limits of agreement between control TOF
- Onset time
- Time to reappearance of T1, T2, T3 and T4
- Twitch height of T1 at reappearance of T1, T2, T3 and T4
- Time to T1=25%
- Interval 25-75%
- Time to TOF-ratio = 0.9 and 1.0
- Time to final T1
- Time to final TOF ratio
Study Sites (1)
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