NCT00472121
Completed
Not Applicable
The Precision and Arm-to-Arm Variation og Mechanomyography and Acceleromyography for Monitoring the Neuromuscular Block During Anesthesia, A Randomized Controlled Study
ConditionsNeuromuscular Blockade
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Neuromuscular Blockade
- Sponsor
- Rigshospitalet, Denmark
- Locations
- 1
- Primary Endpoint
- Precision at the contralateral arms using the average residual coefficient of variation over subsequent linear regressions (detrending) over time
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
The purpose of the study is the examine the precision of acceleromyography and mechanomyography during recovery from a neuromuscular blocking agent and to examine whether there is any difference in monitoring block at the dominant or non-dominant arm. Our hypothesis is that there is no significant difference in neither the precision nor the level of block in the contralateral arms.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA I-III
- •General anesthesia \>1 hour
- •Surgery in supine position w. possibility of monitoring the neuromuscular block at both arms (n. ulnaris stimulation/thumb response)
- •Written informed content
Exclusion Criteria
- •Neuromuscular disorders, hepatic and renal dysfunction
- •Medication expected to interfere with the neuromuscular blocking agent
- •Allergy to any medication used during anaesthesia
- •Body weight less or exceeding 20% of ideal body weight
- •Pregnancy or breastfeeding
Outcomes
Primary Outcomes
Precision at the contralateral arms using the average residual coefficient of variation over subsequent linear regressions (detrending) over time
Secondary Outcomes
- Bias and limits of agreement between control TOF, reappearance of T1, T2, T3, T4
- Time to TOF 0.9 and 1.0 with and without normalization
- Time to stable T1 and stable TOF
- T1 height at reappearance of T1-T4
- Interval 25-75%
- Time to T1=25%
Study Sites (1)
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