Exercise Training and Hepatic Metabolism in Overweight/Obese Adolescent
- Conditions
- Lipid Metabolism DisordersObesityMetabolic Syndrome XMental Health Wellness 1Body Composition, Beneficial
- Interventions
- Behavioral: Low physical activity programBehavioral: Low and High physical activity programBehavioral: High physical activity programBehavioral: Conventional physical activity program
- Registration Number
- NCT02753231
- Lead Sponsor
- Universidad Santo Tomas
- Brief Summary
The HEPAFIT Study aims to examine whether a 6-months physical education program has benefits on hepatic metabolism and cardiovascular health as well as on selected physical fitness and mental health outcomes among adolescent overweight/obese from Bogota, Colombia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
- Overweight or obesity status
- 11-17 years old
- Written informed consent
- Interested in improving health and fitness
- Any other conditions which, in opinion of the investigators, would adversely affect the conduct of the trial.
- Clinical diagnosis of diabetes
- Pregnancy
- Drugs/alcohol abuse
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Low physical activity program Low physical activity program Three Physical Education sessions / week Low and High physical activity program Low and High physical activity program Three Physical Education sessions / week (increased volume and intensity) High physical activity program High physical activity program Three Physical Education sessions / week (increased volume) Conventional physical activity program Conventional physical activity program One Physical Education sessions / week
- Primary Outcome Measures
Name Time Method Change from Baseline in hepatic fat measured by controlled attenuation parameter values (FibroScan®) Baseline and 6 months Changes in hepatic fat fraction measured by controlled attenuation parameter after the 6 months intervention program
- Secondary Outcome Measures
Name Time Method Change from Baseline in Body composition Baseline and 6 months Lean body mass as measured by Dual Energy X-ray Absorptiometry
Changes in liver enzymes Baseline and 6 months Changes in total aspartate transaminase (AST) after the 6 months intervention program
Changes in serum lipid profile Baseline and 6 months Changes in cholesterol total, LDL cholesterol, HDL cholesterol and triglycerides after the 6 months intervention program
Change from Baseline in Muscular Fitness assessed using handgrip test (maximum handgrip strength assessment) Baseline and 6 months Muscular fitness will be assessed using handgrip test (maximum handgrip strength assessment) using a standard adjustable handle analogue handgrip dynamometer T-18 TKK SMEDLY III®
Changes in Insulin sensitivity measured by homeostasis model assessment (HOMA) Baseline and 6 months Changes in insulin sensitivity measured by homeostasis model assessment (HOMA) after the 6 months intervention program
Change from Baseline in Aerobic fitness measured on a maximum effort test Baseline and 6 months Change from Baseline in Cardiorespiratory fitness measured on a maximum effort test
Change from Baseline in Quality & satisfaction with life by SF Community - short-form survey (SF-12™) Colombian version Baseline and 6 months Changes in blood pressure Baseline and 6 months Changes in blood pressure after the 6 months intervention program
Changes in physical activity using accelerometry Baseline and 6 months Changes in physical activity estimated by accelerometry after the 6 months intervention program
Changes in inflammatory markers after the 6 months intervention program Baseline and 6 months Changes in C-reactive protein (CRP) after the 6 months intervention program