Fullbrain study
- Conditions
- Overeating, obesity, overweight over eaten, obesitas, overgewicht
- Registration Number
- NL-OMON29447
- Lead Sponsor
- Wageningen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
•Right handed (Left and right handed people show differences in brain activation when tasting)
•Between 18-35 years old at the day of inclusion
Exclusion Criteria
•Failing to meet one or more of the inclusion criteria
•Women: being pregnant, having the intention to become pregnant within half a year.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in brain activity in rest and in reactivity (BOLD signal) upon oro-sensory exposure to food, between hungry and progressive satiated states. <br /><br><br /><br>Regions of interest (ROI) are:<br /><br>•Satiation: Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus<br /><br>•Taste perception: primary: Insula, overlying operculum, secondary: orbitofrontal cortex, Thalamus<br /><br>•Reward: striatum (nucleus accumbens, Putamen), amygdala, Hippocampus, Midbrain (Ventral tregmental area (VTA), substantia nigra), medial pre frontal cortex.<br /><br><br /><br>In addition to these ROI we are interested in brain activity networks (functional connectivity).<br>
- Secondary Outcome Measures
Name Time Method Secondary outcome is stomach filling (ml) measured by MRI.