Effect of time restricted feeding on hepatic glycogen depletion and insulin sensitivity in adults with type 2 diabetes

Completed

• Conditions: adult-onset diabetes; type 2 diabetes; 10018424

• Registration Number: NL-OMON48230
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 34

Inclusion Criteria

Well-controlled, non-insulin treated type 2 diabetes, males and postmenopausal
females, age: 50 - 75, BMI: >25 kg/m2, habitual eating times spread over a time
period of 14 hours

Exclusion Criteria

Not being able to adhere to a restricted feeding schedule, use of medication
that interferes with the study outcomes as determined by the dependent
physician, extreme early bird or extreme night person, any medical condition
that will preclude the safe performance of the measurements

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study endpoint is the effect of time restricted feeding on morning<br /><br>(fasted) hepatic glycogen content, measured with 13C-Magnetic Resonance<br /><br>Spectrometry (MRS).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The main secondary outcome is the effect of TRF on insulin sensitivity,<br /><br>measured with the hyperinsulinemic 2-step clamp. </p><br>