Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults
- Conditions
- Percutaneous Coronary InterventionCoronary Artery Disease
- Registration Number
- NCT02496858
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Brief Summary
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.
- Detailed Description
During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.
The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.
The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2000
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel 36 months Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
Number of patients developing stroke 36 months Any events of ishcemic stroke, TIA or hemorrhagic stroke
Number of cardiac death 36 months Any death from cardiac conditions
Number of patients developing myocardial infarction 36 months Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
- Secondary Outcome Measures
Name Time Method Number of stent thrombosis, bleedingγnon-cardiac death and all-cause death. 36 months Composite of stent thrombosis, bleedingγnon-cardiac death and all-cause death.
Trial Locations
- Locations (38)
Xuzhou Fourth People's Hospital
π¨π³Xuzhou, Jiangsu, China
Affiliated Hospital of Zunyi Medical College
π¨π³Zunyi, Guizhou, China
China-Japan Friendship Hospital
π¨π³Beijing, Beijing, China
Xiamen Cardiovascular Hospital
π¨π³Xiamen, Fujian, China
The First Hospital of Lanzhou University
π¨π³Lanzhou, Gansu, China
Zhuhai Hospital of Guangdong Provincial People's Hospital
π¨π³Zhuhai, Guangdong, China
Wuhan Asia Heart Hospital
π¨π³Wuhan, Hubei, China
Guangdong Provincial People's Hospital
π¨π³Guangzhou, Guangdong, China
The second Hospital of Hebei Medical University
π¨π³Shijiazhuang, Hebei, China
Sun yat-sen Memorial Hospital
π¨π³Guangzhou, Guangdong, China
Shanghai Zhongshan Hospital
π¨π³Shanghai, Shanghai, China
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
π¨π³Nanning, Guangxi, China
Wuxi Third People's Hospital
π¨π³Wuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University
π¨π³Nanchang, Jiangxi, China
The second Hospital of Jilin University
π¨π³Chang chun, Jilin, China
General Hospital of Ningxia Medical University
π¨π³Yinchuan, Ningxia, China
The First Affiliated Hospital of Xi 'an Jiaotong University
π¨π³Xi'an, Shaanxi, China
Central Hospital of Jiading District
π¨π³Shanghai, Shanghai, China
Central Hospital of Minhang District
π¨π³Shanghai, Shanghai, China
Central Hospital of Yangpu District
π¨π³Shanghai, Shanghai, China
Yan'an Hospital of Kunming City
π¨π³Kunming, Yunnan, China
Yueyang hospital
π¨π³Shanghai, Shanghai, China
Changhai Hospital of Second Military Medical University of Chinese PLA
π¨π³Shanghai, Shanghai, China
Shanghai Changzheng Hospital
π¨π³Shanghai, Shanghai, China
Shanghai Tongren Hospital
π¨π³Shanghai, Shanghai, China
Shanghai chest hospital
π¨π³Shanghai, Shanghai, China
Taiyuan central hospital
π¨π³Taiyuan, Shanxi, China
Shanghai Shidong Hospital
π¨π³Shanghai, Shanghai, China
Tongji Hospital of Tongji University
π¨π³Shanghai, Shanghai, China
Shanghai First People's Hospital
π¨π³Shanghai, Shanghai, China
Zhenjiang First People's Hospital
π¨π³Hangzhou, Zhenjiang, China
Shanghai Ninth People's Hospital
π¨π³Shanghai, Shanghai, China
Shanghai Sixth People's Hospital
π¨π³Shanghai, Shanghai, China
Shanxi cardiovascular hospital
π¨π³Taiyuan, Shanxi, China
Tianjin Chest Hospital
π¨π³Tianjin, Tianjin, China
Karamay Central Hospital
π¨π³Karamay, Xinjiang, China
Tenth People's Hospital of Tongji University
π¨π³Shanghai, Shanghai, China
Second Affiliated Hospital of Zhejiang University
π¨π³Hangzhou, Zhejiang, China