Molecular Determinants of Coronaruy Artery Disease

Terminated

• Conditions: Myocardial Infarction; Coronary Artery Disease; Arteriovenous Malformations

• Registration Number: NCT00590291
• Lead Sponsor: John Barnard

Brief Summary

The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM).

Detailed Description

The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM). Many human diseases are inherited or passed from parent to child in families. These diseases occur because of damage to a gene(s), the genetic material that is also called DNA. Scientists can now use modern molecular techniques to locate and to find certain genes within the DNA (genetic material) of a person, and to follow their inheritance in a family. To find these disease-causing genes requires studies of many affected with the disease and their family members. The purpose of this study is to locate and to find the genes for coronary artery disease (CAD) which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages; or, arteriovenous malformation (AVM) which causes abnormal vascular connections between arteries and veins, particularly near the heart. Findings of the genes causing CAD and AVM will have far-reaching effect on the diagnosis, treatment, and prevention of coronary artery disease and arteriovenous malformation. These studies will lead to possible genetic diagnosis, early detection of persons at risk for developing CAD or AVM (even in the absence of symptoms), development of effective drugs, more rational and specific therapeutic interventions, treatments and ultimately, prevention of coronary heart disease. Approximately 3-5 years are required to find one human disease gene.

Study Timeline

• Study Start: 1995-01
• Study First Submitted: 2007-12-27
• Study First Submitted QC: 2007-12-27
• Study First Posted: 2008-01-10
• Primary Completion: 2021-04-01
• Study Completion: 2021-04-01
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-13
• Last Update Posted: 2021-05-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 1461

Inclusion Criteria

• Males at least 45 years old and premenopausal females at least 50 years old at the time of onset of any of the following:
• PTCA
• MI
• CABG
• Must have a living sibling meeting the same criteria.

Exclusion Criteria

• Substance Abuse in the absence of angiographic coronary stenosis
• Congenital Heart Disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary Artery Disease	2009
Arteriovenous Malformation	2009

Secondary Outcome Measures

Name	Time	Method
Myocardial Infarction	2009

Trial Locations

Locations (1)

Cleveland Clinic; 🇺🇸 Cleveland, Ohio, United States