Clinical effect evaluation and mechanism discussion of bupleurum xuanfuhua decoction in intervention of hashimoto thyroiditis
Not Applicable
Recruiting
- Conditions
- Hashimoto's thyroiditis
- Registration Number
- ITMCTR2000003971
- Lead Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1. Comply with the diagnostic criteria of Hashimoto's thyroiditis with hypothyroidism(including subclinical hypothyroidism), TCM syndrome differentiation is liver spleen deficiency, phlegm and blood stasis type;
2. Adult patients aged 18 to 65 years;
3. Signing informed consent.
Exclusion Criteria
1. A history of malignant tumors of the thyroid gland;
2. Patients with severe heart, liver, kidney, blood system diseases or severe mental illness;
3. Pregnant or lactating women;
4. Those who are allergic to drugs;
5. Patients with hyperthyroidism.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Foxp3, ROR?t;TG-Ab, TPO-Ab;Depression and anxiety assessment;Thyroid volume and isthmus thickness;QOL;Treg/Th17;TCM symptoms and physical signs;TT3, TT4, FT3, FT4, TSH;TGF-ß, IFN-?, IL-2, IL-6, IL-10, IL-17, IL-23;
- Secondary Outcome Measures
Name Time Method body weight;memory;fasting plasma glucose;blood lipoid;glycosylated hemoglobin;