Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients
- Conditions
- Heart Failure
- Registration Number
- NCT01113866
- Lead Sponsor
- University of Parma
- Brief Summary
Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.
- Detailed Description
Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 124
- symptomatic congestive heart failure lasting at least six months
- reduced exercise tolerance
- impaired or preserved left ventricular ejection fraction
- cardiomegaly
- acute infection
- rheumatoid or other autoimmune diseases
- primary cachectic states (cancer, thyroid disease, severe liver disease)
- severe chronic lung disease
- neuromuscular disorders
- myocardial infarction within the previous 20 weeks
- diabetes mellitus
- chronic renal failure (serum creatinine level > 2.0 mg/dl, >177 micromol/L)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Università di Parma
🇮🇹Parma, Italy