NCT00238862
Completed
Not Applicable
Efficacy of Amniotic Membrane Transplantation and Autologous Serum in Treatment of Persistent Epithelial Defects
ConditionsCorneal Epithelial Defect
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Corneal Epithelial Defect
- Sponsor
- King Khaled Eye Specialist Hospital
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Corneal re-epithelialization (= initial success)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Patients with persistent corneal epithelial defects who have not responded to conventional therapy will be randomized to treatment with either amniotic membrane transplantation or autologous serum 20%. Outcome measures will be (1) presence or absence of complete re-epithelialization within 28 days and (2) retention of intact epithelium for at least 90 days.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Corneal epithelial defect of more than 14 days that has not responded to conventional therapy
Exclusion Criteria
- •Under age 18
- •Pregnant/lactating females
- •Patients with hemoglobin levels \< 12 mg/ml
- •Patients with limbal stem cell deficiency
Outcomes
Primary Outcomes
Corneal re-epithelialization (= initial success)
Persistent corneal re-epithelialization (= lasting success)
Study Sites (1)
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