Treatment of PED With AMT and Autologous Serum
Not Applicable
Completed
- Conditions
- Corneal Epithelial Defect
- Registration Number
- NCT00238862
- Lead Sponsor
- King Khaled Eye Specialist Hospital
- Brief Summary
Patients with persistent corneal epithelial defects who have not responded to conventional therapy will be randomized to treatment with either amniotic membrane transplantation or autologous serum 20%. Outcome measures will be (1) presence or absence of complete re-epithelialization within 28 days and (2) retention of intact epithelium for at least 90 days.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
- Corneal epithelial defect of more than 14 days that has not responded to conventional therapy
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Exclusion Criteria
- Under age 18
- Pregnant/lactating females
- Patients with hemoglobin levels < 12 mg/ml
- Patients with limbal stem cell deficiency
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Corneal re-epithelialization (= initial success) Persistent corneal re-epithelialization (= lasting success)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
King Khaled Eye Specialist Hospital
🇸🇦Riyadh, Saudi Arabia