Mechanisms of Remote Ischaemic PreConditioning in humans

Completed

• Conditions: organprotection; 10011082; 10047079

• Registration Number: NL-OMON37484
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Healthy, male volunteers aged 18-45 years.

Exclusion Criteria

Cardiovascular diseases, Alcohol or drug abuse, Fibrinolytic treatment in the previous 30 days, Usage of the anti-diabetic drug glibenclamide (this drug is known to block any conditioning effect).
Doing any kind of sports on the night before the experimental day in the AMC

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint of this study will be apoptosis, caspase 3/8/9 activity<br /><br>and LDH release measured at different time points in our in vitro models. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary endpoints will be targets that will be analyzed from the<br /><br>Reperfusion Injury Salvage Kinase (RISK) pathway.</p><br>