Review of Trend in Incidence and Characteristics of Hospital-acquired Acute Kidney Injury in Hospital Selayang

Completed

• Conditions: Acute Renal Failure; Kidney Failure, Acute; Acute Kidney Injury; Hospital Acquired Condition
• Interventions: Other: HA-AKI; Other: No AKI; Other: CA-AKI

• Registration Number: NCT03353389
• Lead Sponsor: Selayang Hospital

Brief Summary

This retrospective cohort study aims to investigate the incidence, risk factors and outcomes of Hospital-acquired Acute Kidney Injury in Hospital Selayang, a tertiary hospital at Malaysia, over 15 years.

Detailed Description

This is a retrospective cohort study involving 5-yearly trend from 2002 to 2017 for analysis. Laboratory serum creatinine (SCr) results of all patients admitted during study period will be retrieved from the hospital Laboratory Information System. A preliminary screening list will be generated by using STATA program from the SCr results. The nephrologist will then determine HA-AKI and CA-AKI as per inclusion and exclusion criteria. Data collectors will collect all relevant data from these patients.

Study Timeline

• Study Start: 2017-11-01
• Study First Submitted: 2017-11-18
• Study First Submitted QC: 2017-11-22
• Study First Posted: 2017-11-27
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-18
• Last Update Posted: 2022-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 170000

Inclusion Criteria

• Adult admissions to Hospital Selayang from

  • 1st July 2001 to 30th June 2002
  • 1st July 2006 to 30th June 2007
  • 1st July 2011 to 30th June 2012
  • 1st July 2016 to 30th June 2017

Exclusion Criteria

• End Stage Renal Failure and on Renal Replacement Therapy (Hemodialysis, peritoneal dialysis or Renal Transplant)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HA-AKI	HA-AKI	Adult admissions with Acute Kidney Injury diagnosed after 48 hours during their stay (Hospital-acquired Acute Kidney Injury)
No AKI	No AKI	Adult admissions without Acute Kidney Injury during their stay
CA-AKI	CA-AKI	Adult admissions with Acute Kidney Injury diagnosed within 48 hours during their stay (Community-acquired Acute Kidney Injury)

Primary Outcome Measures

Name	Time	Method
Incidence of Hospital-acquired Acute Kidney Injury	During admissions to study site (Year 2001-2002, Year 2006-2007, Year 2011-2012, Year 2016-2017)	Incidence of Hospital-acquired Acute Kidney Injury among the adult admissions

Secondary Outcome Measures

Name	Time	Method
Renal Recovery from Hospital-acquired Acute Kidney Injury	90 days after diagnosis of Acute Kidney Injury	Renal Recovery among adult admissions for Hospital-acquired Acute Kidney Injury
In-hospital Mortality from Hospital-acquired Acute Kidney Injury	During admissions to study site with Hospital-acquired Acute Kidney Injury, through study completion (an average of 1 year)	Mortality rate among adult admissions for Hospital-acquired Acute Kidney Injury

Trial Locations

Locations (1)

Selayang Hospital; 🇲🇾 Batu Caves, Selangor Darul Ehsan, Malaysia