Third generation autofluorescence endoscopy compared with conventional autofluorescence endoscopy for the detection of early neoplasia in Barrett’s oesophagus.
Recruiting
- Conditions
- Barrett's oesophagusearly neoplasiaBarrett slokdarmvroege neoplasie
- Registration Number
- NL-OMON21252
- Lead Sponsor
- AMC Amsterdam
- Brief Summary
Curvers WL, Herrero LA, Wallace MB, e.a. Endoscopic tri-modal imaging is more effective than standard endoscopy in identifying early-stage neoplasia in Barrett’s esophagus. Gastroenterology. 2010;139(4):1106-1114.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 84
Inclusion Criteria
1. Age over 18 years;
2. Prior diagnosis of BO defined as columnar lined esophageal epithelium upon endoscopy and intestinal metaplasia upon histological assessment of esophageal biopsies;
Exclusion Criteria
1. Active erosive esophagitis grade B or higher according to the Los Angeles classification of erosive oesophagitis [17]17;
2. Advanced neoplastic lesion (i.e. any lesion considered not amendable for endoscopic treatment based its endoscopic appearance);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Overall histological yield of AFI II and AFI III;<br /><br>2. Targeted histological yield of AFI II and AFI III;<br /><br>3. Number of patients diagnosed with HGIN/EC by AFI II and AFI III.
- Secondary Outcome Measures
Name Time Method 1. Number of abnormalities detected by AFI II and AFI III;<br /><br>2. The value of re-inspection of AFI-positive areas with WLE;<br /><br>3. The value of re-inspection of AFI-positive areas with NBI.