Evaluation of the Reproducibility of a Fatigability Test Fitted to Patients With Spinal Muscular Atrophy

Not Applicable

Not yet recruiting

Conditions: Spinal Amyotrophy
Infantile Spinal Muscular Atrophy
Juvenile Spinal Muscular Atrophy

Registration Number: NCT06562283

Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Not yet recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Inclusion Criteria: - Genetically confirmed spinal muscular atrophy - Age = 6 years - No orthopaedic surgery in the 6 months prior to inclusion - Informed consent signed by the patient(s) or parent(s)/legal guardian(s) and assent of the patient - Affiliated or beneficiary of a health insurance scheme (for inclusion in France) Exclusion Criteria: - Other condition that may significantly interfere with the assessment of the SMA and which is clearly unrelated to the disease - Other associated neurological disease - Joint deformities that prevent correct and comfortable positioning with the various different measuring devices (thumb-index clamp, handgrip and QIF-test) - Contraindication to transcranial magnetic stimulation

Exclusion Criteria

Not provided

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feasibility of a fatigability test adapted to the motor level of the entire population of patients with spinal muscular atrophy.

Secondary Outcome Measures

Name	Time	Method
Tolerance of fatigability test - Pain;Tolerance of fatigability test - RPE;Tolerance of fatigability test - AEs;Reproducibility of the fatigability test;Reproducibility of the central and peripheral components of fatigue - VA;Reproducibility of the central and peripheral components of fatigue - magnetic jerk;Perceived fatigue - FACIT-F;Perceived fatigue - PedsQL 4.0