High Nucleotide Meal Consumption in Uric Acid and Metabolic Health

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Low nucleotide meal; Other: High nucleotide meal

• Registration Number: NCT03568864
• Lead Sponsor: University of Exeter

Brief Summary

The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health.

Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers.

The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-31
• Primary Completion: 2018-03-14
• Study Completion: 2018-03-14
• Study First Submitted: 2018-05-31
• Status Verified: 2018-06
• Study First Submitted QC: 2018-06-13
• Last Update Submitted: 2018-06-13
• Study First Posted: 2018-06-26
• Last Update Posted: 2018-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• BMI between 18 and 30

Read More

Exclusion Criteria

• On medication (except contraception)
• Smokers
• Diagnosed with any metabolic or cardiovascular conditions
• BMI < 18 or > 30

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low nucleotide meal	Low nucleotide meal	Mixed meal containing mycoprotein with a reduced nucleotide content (\~ 2% nucleotides)
High nucleotide meal	High nucleotide meal	Mixed meal containing mycoprotein with a high nucleotide content (\~ 10% nucleotides)

Primary Outcome Measures

Name	Time	Method
Changes in serum uric acid concentrations over a 24 h period	Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 8, 12 and 24 hours after meal

Secondary Outcome Measures

Name	Time	Method
Serum insulin	Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal
Blood glucose	Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 24 hours after meal
Branched chained amino-acids	Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal

Trial Locations

Locations (1)

St Luke's Campus - University of Exeter; 🇬🇧 Exeter, Devon, United Kingdom