High Nucleotide Meal Consumption in Uric Acid and Metabolic Health
- Conditions
- Healthy
- Registration Number
- NCT03568864
- Lead Sponsor
- University of Exeter
- Brief Summary
The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health.
Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers.
The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- BMI between 18 and 30
- On medication (except contraception)
- Smokers
- Diagnosed with any metabolic or cardiovascular conditions
- BMI < 18 or > 30
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Changes in serum uric acid concentrations over a 24 h period Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 8, 12 and 24 hours after meal
- Secondary Outcome Measures
Name Time Method Serum insulin Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal Blood glucose Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 24 hours after meal Branched chained amino-acids Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal
Trial Locations
- Locations (1)
St Luke's Campus - University of Exeter
🇬🇧Exeter, Devon, United Kingdom
St Luke's Campus - University of Exeter🇬🇧Exeter, Devon, United Kingdom