NCT01277627Unknown不适用
Influence of Nevirapine on HCV Viral Load Among HIV/HCV-coinfected Patients
Valme University Hospital1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2011年1月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Changes in HCV viral load
研究概览
简要总结
Nevirapine-based antiretroviral therapy is associated with lower plasma HCV viral load in HIV/HCV-coinfected individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV infection.
- •Older than 18 years.
- •Chronic hepatitis C.
- •Undetectable HIV viral load during one year before starting study.
- •To have not received HCV therapy during one year before starting study.
- •To have not started efavirenz or protease inhibitors o nucleoside analogs during 6 months before starting study.
- •Non contraindications for drugs included in this study.
- •To change an antiretroviral regimen including efavirenz or protease inhibitors by nevirapine due to side effects, interactions or pregnancy (NVP group)
- •To continue with a antiretroviral regimen including efavirenz or protease inhibitors (non-NVP group)
- •Both groups will be matched according to these variables:
- •Liver stiffness.
- •HCV genotype.
- •Hospital.
- •Time from starting antiretroviral therapy.
- •Previous third drug (EFV or PI) to introduction of NVP.
排除标准
- •HCV therapy during follow-up
研究组 & 干预措施
Nevirapine
Active Comparator
干预措施: Nevirapine (Drug)
Nevirapine
Active Comparator
干预措施: efavirenz, protease inhibitors (Drug)
Non-nevirapine
Active Comparator
干预措施: Nevirapine (Drug)
Non-nevirapine
Active Comparator
干预措施: efavirenz, protease inhibitors (Drug)
结局指标
主要结局
Changes in HCV viral load
时间窗: 48 weeks
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Intrahepatic HCV RNA and Telaprevir Kinetics in Hepatitis C Virus (HCV)Hepatitis CNCT00892697Weill Medical College of Cornell University15
已完成
4 期
Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)HIV/AIDSHIV InfectionsNCT00829114FHI 360370
已完成
不适用
Nevirapine Clearance After Short-term Highly Active Antiretroviral Therapy (HAART) for Prevention of Mother to Child Transmission of HIV (PMTCT)NVP Plasma LevelNVP Related Mutation3TC Related MutationNCT00872872Thai Red Cross AIDS Research Centre30
已完成
不适用
Nevirapine Levels and FluconazoleNevirapineFluconazoleAdverse EventNCT00309582Bamrasnaradura Infectious Diseases Institute
已完成
不适用
The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the BloodHerpes SimplexHIV InfectionsNCT00001115National Institute of Allergy and Infectious Diseases (NIAID)75