asal noninvasive high frequency oscillatory ventilation in premature infants below 32 weeks gestational age - a pilot study
Not Applicable
- Conditions
- CO2 clearance using nasal high frequency oscillation
- Registration Number
- DRKS00007171
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
1. Premature infants < 32 weeks gestational age
2. 0-24 h after extubation or 0-24 hours after application of Surfactant
3. Respiratory insuficiency on non-invasive respiratory support (nasal CPAP)
3. PCO2 > 45 mmHg
4. Informed consent of caretakers
Exclusion Criteria
1. Upper airway malformation leading to incompatibility with noninvasive ventilation
2. Known chomosomal abnormalities
3. Palliative/comfort care only.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Invasive measurement of partial pressure of carbon dioxide after 4 h nHFOV vs 4 h nCPAP
- Secondary Outcome Measures
Name Time Method •Amplitude to achieve visible, adequate oscillation<br>•mean airway pressure<br>•need for intubation (failure of noninvasive ventilation per period)<br>•Number of apnea/bradycardia per period<br>•Respiratory rate*<br>•Heart rate*<br>•EDIN-Painscore*<br>•SpO2*<br>•FiO2*<br>•pO2*<br>•Transcutaneous pCO2<br><br>*after 4 hours of each type of ventilation <br>