Effect of Intravenous Low-Dose Ketamine Infusion With Intravenous Lignocaine Infusion on Post-Operative Pain in Patients Undergoing Laparoscopic Choleysystectomy Under General Anesthesia

Phase 4

Completed

• Conditions: Cholelithiases
• Interventions: Drug: Intravenous lignocaine; Drug: Intravenous Ketamine Infusions

• Registration Number: NCT06964555
• Lead Sponsor: Fazaia Ruth Pfau Medical College

Brief Summary

Objective: To determine the effect of low-dose ketamine versus lignocaine on post-operative pain in patients undergoing LC under general anesthesia in a tertiary care hospital.

Sample Selection: Patients of both the gender of age at least 18 years, planned for elective LC with ASA grade I-II were included. Patients with obesity, history of alcohol consumptions, drug abusers, uncontrolled hypertension and diabetics, with chronic pain, allergic to study drugs, having neurological disorders, unable to understand pain scoring system and converted to open LC were excluded.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-11-30
• Study Completion: 2024-12-31
• Status Verified: 2025-05
• Study First Submitted: 2025-05-01
• Study First Submitted QC: 2025-05-01
• Study First Posted: 2025-05-09
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients of both the gender of age at least 18 years
• Patients planned for elective LC
• Patients with ASA grade I-II were included.

Exclusion Criteria

• Patients with obesity,
• Patients with history of alcohol consumptions, uncontrolled hypertension and diabetics,
• Drug abusers
• Patients with chronic pain
• Patients allergic to study drugs
• Patients having neurological disorders or unable to understand pain scoring system
• Patients converted to open LC

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group L	Intravenous lignocaine	Just before the skin incision intravenous lignocaine was given.
Group K	Intravenous Ketamine Infusions	Just before the skin incision, intravenous ketamine was given

Primary Outcome Measures

Name	Time	Method
Post operative Pain	24 hours	Pain was assessed using Numeric Rating Scale which is a ten point scoring scale ranging from 0-10 for ranking pain where 0 means no and 10 means worst pain.

Secondary Outcome Measures

Name	Time	Method
Wound Closure	End of Surgery	The time between the incision and the wound's closure was used to define the length of the surgery.
Time to rescue analgesia	24 hours	Time to rescue analgesia was defined as time point at which patient will be given first rescue analgesia for pain of score more 5 or above.

Trial Locations

Locations (1)

Fazaia Ruth Pfau Medical College; 🇵🇰 Karachi, Sindh, Pakistan