Positron Emission Tomography of Infection and Vasculitis

Completed

• Conditions: Infection; Vasculitis
• Interventions: Radiation: PET/CT

• Registration Number: NCT01878721
• Lead Sponsor: Turku University Hospital

Brief Summary

The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.

Detailed Description

The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to:

1. investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia.

2. study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp.

3. find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis.

4. study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator.

5. investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2013-06-10
• Study First Submitted QC: 2013-06-14
• Study First Posted: 2013-06-17
• Status Verified: 2021-10
• Primary Completion: 2021-10
• Study Completion: 2021-10
• Last Update Submitted: 2021-10-21
• Last Update Posted: 2021-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 117

Inclusion Criteria

Adults with

• Staphylococcus aureus bacteremia or
• Salmonella spp. bacteremia or
• infective endocarditis or
• infection of pacemaker or implantable cardioverter defibrillator or
• vasculitis

Exclusion Criteria

• underage, pregnant, breastfeeding, handicapped or prisoner

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Staphylococcus aureus bacteremia	PET/CT	PET/CT in patients with Staphylococcus aureus bacteremia
Salmonella spp. bacteremia	PET/CT	PET/CT in patients with Salmonella spp. bacteremia
Pacemaker infection	PET/CT	PET/CT in patients with pacemaker infection
Endocarditis	PET/CT	PET/CT in patients with infective endocarditis
Vasculitis	PET/CT	PET/CT in patients with vasculitis

Primary Outcome Measures

Name	Time	Method
Detection of infection or vasculitis in PET images	within 1 week after starting the treatment

Secondary Outcome Measures

Name	Time	Method
Standardized uptake value of PET imaging agent at the site of infection or vasculitis	within 1 week after starting the treatment

Trial Locations

Locations (1)

Turku University Hospital; 🇫🇮 Turku, Finland