HIT in People With Type 1 Diabetes

Not Applicable

Completed

• Conditions: Type1diabetes
• Interventions: Other: HIT; Other: MICT

• Registration Number: NCT03545841
• Lead Sponsor: Liverpool John Moores University

Brief Summary

Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

Detailed Description

This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.

Study Timeline

• Study Start: 2015-03-09
• Primary Completion: 2017-10-10
• Study Completion: 2017-10-10
• Study First Submitted: 2018-05-09
• Status Verified: 2018-06
• Study First Submitted QC: 2018-06-01
• Last Update Submitted: 2018-06-01
• Study First Posted: 2018-06-04
• Last Update Posted: 2018-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 14

Inclusion Criteria

• duration of type 1 diabetes >6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history)

Exclusion Criteria

duration of type 1 diabetes <6 months,

• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI >30 kg∙m-2)
• pregnancy or planning pregnancy
• uncontrolled hypertension (>180/100 mmHg)
• angina, autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative
• unstable proliferative retinopathy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HIT training	HIT	6 weeks of high-intensity interval training (HIT)
Moderate intensity training	MICT	6 weeks of moderate-intensity continuous training (MICT)

Primary Outcome Measures

Name	Time	Method
Maximal aerobic capacity	change in baseline maximal aerobic capacity at 6 weeks	Maximal aerobic capacity test pre and post 6-week training intervention

Secondary Outcome Measures

Name	Time	Method
Vascular stiffness	change in baseline vascular stiffness at 6 weeks	Aortic pulse wave velocity to measure vascular stiffness

Trial Locations

Locations (1)

Liverpool John Moores University; 🇬🇧 Liverpool, Merseyside, United Kingdom