New Method Using Deuterium Labelled Creatine to Measure Total Body Skeletal Muscle Mass
Not Applicable
Completed
- Conditions
- Sports Nutritional Sciences
- Registration Number
- NCT02519751
- Lead Sponsor
- GlaxoSmithKline
- Brief Summary
Creatine (methyl-d3) dilution (D3-creatine) is a novel technique for the estimation of muscle mass. The method uses a dose of deuterium-labelled creatine to determine total skeletal muscle mass via estimation of total body creatine pool size.The aim of this study is to compare estimates of total body skeletal muscle mass by D3-creatine dilution method and whole body Magnetic Resonance Imaging (MRI) in an athletic population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Trained and competing elite canoe athletes will be recruited, who represent Great Britain Canoeing
Exclusion Criteria
- Pregnant and lactating women
- Intolerance or hypersensitivity to Creatine supplementation
- Athletes with disabilities which affect their total body muscle mass
- If creatine was taken in a supplemented form, rather than dietary intake, more regularly than once a week within 6-weeks of assessment commencing
- Contraindication to an MRI scan
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Correlation between muscle mass obtained by MRI method and D3-Creatine method Upto 3 months MRI scan of the participants will be done at Day 1 and end of study (i.e.Day 90).D3-Creatine capsule will be given orally at Day 1 and urine samples collected at 0-4h and 4-24h every day from Day 1 to Day 4.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
GSK Investigational Site
🇬🇧Brentford, United Kingdom
GSK Investigational Site🇬🇧Brentford, United Kingdom