Characterisation of the postprandial pharmacokinetics of spermidine in humans. Randomised, placebo-controlled, single-centre study in healthy volunteers; two-arm cross-over design with washout phase
Not Applicable
- Conditions
- healthy subjects
- Registration Number
- DRKS00029397
- Lead Sponsor
- Institut für Ernährungsmedizin, Universitätsklinikum Schleswig-Holstein
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
a) women and men aged 18 - 45 years old
b) sufficient knowledge of German to understand the study documents and the procedure
Exclusion Criteria
a) BMI < 18 kg/m² or > 29.9 kg/m²
b) acute illness
c) history of food allergy (especially soy protein allergy)
d) intake of medicines and food supplements during the period 48 h before the start of the study until the end of the study (exception: oral contraceptives)
e) consumption of illegal substances
f) pregnancy and breastfeeding
g) shift work
h) strict vegan diet
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method time-dependent concentration course of putrescine, spermidine and spermine in blood and saliva (quantified by LC-GC-MS)
- Secondary Outcome Measures
Name Time Method metabolite spectrum in blood (quantified by NMR metabolomics)