A Prospective Randomized Comparison of the Effects of Sevoflurane and Desflurane Anesthesia on QT Interval Measured With Cardiac Electrophysiological Balance Index
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Ankara City Hospital Bilkent
- Enrollment
- 120
- Primary Endpoint
- QTc T4
Study Overview
Brief Summary
The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- Double (Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •ASA I-II-III risk group
- •the operation time is longer than 1 hour in the Urology department.
Exclusion Criteria
- •bundle branch block in preoperative ECG,
- •Non-sinus heart rhythm,
- •QT length in preoperative ECG,
- •using drugs that cause known QT prolongation ( beta-blocker drugs using will be included),
- •development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period,
- •patients with electrolyte disorders,
- •patient refusal -
Arms & Interventions
sevoflurane
General Anesthesia procedure with sevoflurane
Intervention: 12- derivation Electrocardiography (Diagnostic Test)
desflurane
General Anesthesia procedure with desflurane
Intervention: 12- derivation Electrocardiography (Diagnostic Test)
Outcomes
Primary Outcomes
QTc T4
Time Frame: During surgery (at the time of MAC reached 1,3)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1,3 , it will be calculated from the ECG.
QTc T5
Time Frame: During surgery (at the time of MAC reduced 0,3)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reduces 0,3, it will be calculated from the ECG.
iCEB T4
Time Frame: During surgery (at the time of MAC reached 1,3)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG.
QTc T3
Time Frame: During surgery (at the time of MAC reached1)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1, it will be calculated from the ECG.
iCEB T0
Time Frame: Baseline, preoperative
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
iCEB T1
Time Frame: During surgery (at the time of the anesthesia induction)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
iCEB T2
Time Frame: During surgery (at the time of MAC reached 0,6)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG.
QTc T0
Time Frame: Baseline, preoperative
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).
iCEB T5
Time Frame: During surgery (at the time of MAC reduced 0,3)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG.
QTc T1
Time Frame: During surgery (at the time of the anesthesia induction)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).
QTc T2
Time Frame: During surgery (at the time of MAC reached 0,6)
QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 0,6, it will be calculated from the ECG.
iCEB T3
Time Frame: During surgery (at the time of MAC reached 1)
Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG.
Secondary Outcomes
No secondary outcomes reported
Investigators
Işıl Karabeyoğlu
principal investigator
Ankara City Hospital Bilkent