Can nitrate-rich green leafy vegetables lower blood pressure?

Not Applicable

Completed

• Conditions: Blood pressure; Vascular function; Cardiovascular - Hypertension; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12611000609954
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Men and women aged 20 to 70 years with high-normal blood pressure (systolic blood pressure 120-139 mm Hg or diastolic blood pressure 80-89 mm Hg)

Exclusion Criteria

Use of antihypertensive medication; systolic blood pressure < 120 mm Hg or > 139 mm Hg and diastolic blood pressure <80 mm Hg or >89 mm Hg; a diet high in green leafy vegetables; use of antibacterial mouth wash (which kills bacteria responsible for nitrate reduction in the mouth); use of antibiotics (within previous 2 months); current or recent (<12 months) smoking; history of cardiovascular or peripheral vascular disease; recent history of a psychiatric illness or other major illnesses such as cancer; recent history of asthma, renal, liver or gastrointestinal disease, or gout; a change in drug therapy within the previous 3 months, or the likelihood that drug therapy would change during the study; current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight); alcohol intake > 140 g per wk; reported participation in night shift work during the study period; and inability or unwillingness to follow the study protocol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified