NL-OMON38254
Completed
Not Applicable
Multicenter randomized clinical trial in Patients with Juvenile Idiopathic Athritis: Safety and efficacy of vaccination with live attenuated Measles, Mumps, Rubella vaccine - Safety and efficacy of MMR booster vaccination in JIA
niversitair Medisch Centrum Utrecht0 sites135 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- juvenile chronic arthritis
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 135
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- all subtypes of juvenile idiopathic arthritis
- •\- ages 4\-9 (this is at least 2,5 years after initial MMR and before the scheduled booster, usually given between age 9\-10\)
- •\- fifteen healthy adults (age 18\-65\)
Exclusion Criteria
- •\- use of Infliximab (anti\-TNF alpha therapy).
- •\- primary immunodeficiency
- •\- fever less than 48 hour prior to vaccination (here the moment of vaccination will be postponed for 1 month)
- •\- evidence of viral or bacterial infection less than 48hours prior to vaccination (here the moment of vaccination will be postponed for 1 month)
- •\- methylprednisolon pulse therapy less than 1 month prior to vaccination (in these cases, the moment of vaccination will be postponed for 1 month)
- •\- transfusion of blood or bloodprocudts (e.g.) intravenous immunoglobulines (IVIG) in the 3 months prior to vaccination. (in these cases, the moment of vaccination will be postponed for 3 months);for healthy controls:
- •\-serious adverse events to previous MMR vaccination
- •\-Use of immunosuppressive drugs
- •\-Primary immunodeficiency
- •\-Fever less than 48 hour prior to vaccination (here the moment of vaccination will be postponed for 1 month)
Outcomes
Primary Outcomes
Not specified
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