Impact of Atelectasis and Lung Recruitment on RVEDP Measurement in Children Undergoing Cardiac Catheterization for Surveillance Following Orthotropic Heart Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Number of participants with reduction of right ventricular end diastolic pressure of 3mmHg or greater
研究概览
简要总结
Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements to guide post transplant treatment regiments. These procedures are done under general anesthesia which promotes lung tissue collapse (atelectasis). What is not known is the effect of atelectasis on intracardiac pressures which are a critical area of monitoring post-transplant patients for rejection.
详细描述
Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements. These procedures are done under general anesthesia which promotes lung tissue collapse (atelectasis). Atalectaisis is known to alter intra-thoracic pressures and cardiac loading conditions. What is not known is the effect of atelectasis on intracardiac pressures which are a critical area of monitoring post-transplant patients for rejection. Therefore, the aim of this study is to identify if atelectasis impacts the pressure measurements obtained during cardiac catheterization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients having undergone orthotropic heart transplantation
- •Patients requiring routine heart catheterization for post-transplant surveillance
- •General anesthesia
排除标准
- •Patient/parental refusal
- •Patients with suspected or known acute rejection
- •Known anti-rejection medication non-compliance
- •Patients within 1 year following heart transplant
- •Home oxygen requirement
- •Previous lung surgery (e.g., lobectomy) other than biopsy
- •Lung transplantation
- •Known pulmonary fibrosis
- •Known pulmonary hypertension (>1/2 systemic)
- •Sedation without the use of an airway device
- •Active respiratory infection -Inability to provide recruitment breaths >25mmHg -Cardiomegaly
- •Recipient/donor size mismatch
结局指标
主要结局
Number of participants with reduction of right ventricular end diastolic pressure of 3mmHg or greater
时间窗: 10 minutes
Change of the right ventricular end diastolic pressure from pre and post recruitment breaths
次要结局
未报告次要终点
研究者
Adam Adler MD, MS, FAAP
Associate Professor of Anesthesiology
Baylor College of Medicine