Observational Study to Analyze Respiratory System Mechanics Changes and Inflammatory Responses During Orthotopic Liver Transplantation (SPPLIT Trial)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Elastance of Respiratory System, Lung and Chest Wall
研究概览
简要总结
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury. In particular, reperfusion syndrome is characterised by the release of several inflammatory mediators such as cytokines and oxygen free radicals which may contribute to alveolar endothelial barrier dysfunction. The object of this study is to investigate the respiratory system mechanics impairment in its partitioning between lung and chest wall.
We hypothesize that impairment of respiratory system mechanics (of both lung and chest wall) occurs after reperfusion phase of liver. This impairment is associated with the systemic inflammatory response following liver reperfusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •orthotopic liver transplantation
- •valid informed consent
排除标准
- •Age < 18 yrs
结局指标
主要结局
Elastance of Respiratory System, Lung and Chest Wall
时间窗: at 24 hours after liver reperfusion
次要结局
- Inflammatory mediators in plasma samples(baseline, 90 minutes, 3 hours and 24 hours after reperfusion phase)
- Inflammatory mediators in urine samples(baseline, 90 minutes, 3 hours and 24 hours after reperfusion phase)
- Acute respiratory failure(28 days)
- hospital length of stay(28 days)
- Ventilator free days(28 days)
- ICU length of stay(28 days)
研究者
Vito Fanelli MD, PhD
Assistant professor
University of Turin, Italy