Comparative study of skin needling radiofrequency followed by injection of platelet rich plasma on left side of face with injectable platelet rich fibrin on right side of face in patients with acne scars.
- Conditions
- Scar conditions and fibrosis of skin,
- Registration Number
- CTRI/2023/02/049617
- Lead Sponsor
- KAHER University
- Brief Summary
Majority of the acne scars occur on the face, thus impacting the quality of life. One novel modality of treatment is microneedling radiofrequency therapy also known or collagen induction therapy, has become an important treatment modality for acne scars. Initiation of collagen synthesis is achieved by causing minute injury to the dermis with the use of microneedles. The needles are so fine and thin that tissue damage is almost negligible. Electrical signals, triggers the cascade of the healing process, releasing growth signals to undifferentiated cells and resulting in new blood vessels formation and natural tissue remodeling which continues for 8 weeks to 1 year.
This process is combined with platelet rich plasma and injectable platelet rich fibrin. They contain autologous growth factors, which act synergistically with growth factors induced by skin needling in order to enhance the wound-healing response.
Additionally Injectable platelet rich fibrin has demonstrated the ability to release higher concentrations of various growth factors and induced higher fibroblast migration.
Hence, this study is being performed to compare the effectiveness between platelet rich plasma and autologous injectable platelet rich fibrin
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 40
- Patients of above mentioned age group with fitzpatrick skin type 2-5.
- Patients with grade 2-4 acne scars.
- Patients with acne lesions, keloidal tendencies, on oral steroids/anti coagulation, history of bleeding disorders, with active viral/bacterial/fungal infection.
- Pregnancy and Lactation.
- Non consenting patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference of Goodman and Baron Acne scar grading score at baseline and at the end of 12 weeks Primary outcome will be assessed at the end of 12 weeks
- Secondary Outcome Measures
Name Time Method Patient assessment details are recorded and compared with physician assessment details. Assessment is done every 4 weeks for 12 weeks
Trial Locations
- Locations (1)
JN medical college,Dr Prabhakar Kore Hospital,Belagavi
🇮🇳Belgaum, KARNATAKA, India
JN medical college,Dr Prabhakar Kore Hospital,Belagavi🇮🇳Belgaum, KARNATAKA, IndiaDr Siri B VaidyaPrincipal investigator9902253474siribvaidya14@gmail.com