A split face comparative interventional study to evaluate efficacy of microneedling radiofrequency followed by platelet rich plasma vs microneedling radiofrequency followed by autologous injectable platelet rich fibrin in post acne scars.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Difference of Goodman and Baron Acne scar grading score at baseline and at the end of 12 weeks
研究概览
简要总结
Majority of the acne scars occur on the face, thus impacting the quality of life. One novel modality of treatment is microneedling radiofrequency therapy also known or collagen induction therapy, has become an important treatment modality for acne scars. Initiation of collagen synthesis is achieved by causing minute injury to the dermis with the use of microneedles. The needles are so fine and thin that tissue damage is almost negligible. Electrical signals, triggers the cascade of the healing process, releasing growth signals to undifferentiated cells and resulting in new blood vessels formation and natural tissue remodeling which continues for 8 weeks to 1 year.
This process is combined with platelet rich plasma and injectable platelet rich fibrin. They contain autologous growth factors, which act synergistically with growth factors induced by skin needling in order to enhance the wound-healing response.
Additionally Injectable platelet rich fibrin has demonstrated the ability to release higher concentrations of various growth factors and induced higher fibroblast migration.
Hence, this study is being performed to compare the effectiveness between platelet rich plasma and autologous injectable platelet rich fibrin
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of above mentioned age group with fitzpatrick skin type 2-
- •Patients with grade 2-4 acne scars.
排除标准
- •Patients with acne lesions, keloidal tendencies, on oral steroids/anti coagulation, history of bleeding disorders, with active viral/bacterial/fungal infection.
- •Pregnancy and Lactation.
- •Non consenting patients.
结局指标
主要结局
Difference of Goodman and Baron Acne scar grading score at baseline and at the end of 12 weeks
时间窗: Primary outcome will be assessed at the end of 12 weeks
次要结局
- Patient assessment details are recorded and compared with physician assessment details.(Assessment is done every 4 weeks for 12 weeks)