Vitamin C and Percutaneous Coronary Interventio
- Conditions
- Acute myocardial infarction.Acute transmural myocardial infarction of unspecified site Transmural myocardial infarction NOS
- Registration Number
- IRCT201706168698N21
- Lead Sponsor
- Vice Chancellor for research,Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 110
Subjects (men or women) at least 18 years and less than 80 years of age; Ischemic discomfort = 20 min and < 6 hours of duration; ST elevation = 1 mm (= 0.1mV) in two contiguous limb leads OR = 2mm (=0.2mV) in two contiguous precordial leads ; Planned primary PCI within 2 hours of hospital presentation; Planned or concomitant use of aspirin,
clopidogrel, unfractionated heparin, and Glycoprotein IIb/IIIa inhibition with intent to stent the infarct-related artery; Informed consent able to be obtaine
Age =80 years;
Cardiac arrest or arrhythmia requiring chest compressions or cardiopulmonary resuscitation; Current warfarin therapy; Known allergy or contraindication to fibrinolvtics OR aspirin OR heparin OR clopidogrel; Patients with evidence of coronary collaterals (2-3 Rentrop) to the region at risk on previous coronary angiography (at the previous admission);Renal failure(creatinine>4.0 mg/dl).
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Myocardial infarction. Timepoint: before intervention. Method of measurement: clinical history and ECG.;Troponin I. Timepoint: before and 6, 18 hour after PCI. Method of measurement: ELISA.;Creatine Kinase-MB. Timepoint: before and 6,18 hour after PCI. Method of measurement: spectrophotometry.;NGAL. Timepoint: before and 6 hour after PCI. Method of measurement: ELISA.
- Secondary Outcome Measures
Name Time Method