临床试验/NCT04508907

NCT04508907进行中（未招募）4 期

Pilot Study for the Use of Shortened Preemptive Therapy With Glecaprevir/Pibrentasvir (G/P) and Ezetimibe in Hepatitis C Seronegative Solid Organ Transplant Recipients (Kidney, Heart, Lung and/or Pancreas) of Hepatitis C Viremic Donors

Mayo Clinic1 个研究点分布在 1 个国家目标入组 200 人开始时间: 2020年9月10日最近更新: 2025年12月17日

适应症

干预措施

试验速览

阶段: 4 期
状态: 进行中（未招募）
发起方: Mayo Clinic
入组人数: 200
试验地点: 1
主要终点: Rate of prevention of HCV viremia in recipients of HCV viremic solid organs

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

未提供

排除标准

未提供

研究组 & 干预措施

Arm 1: Pre-emptive Treatment Arm

Experimental

Single arm study were all recipients of HCV viremic organs will receive combination therapy.

干预措施: Mavyret (Drug)

结局指标

主要结局

Rate of prevention of HCV viremia in recipients of HCV viremic solid organs

时间窗: 3 months

The study will assess the percentage of patient who will not become HCV viremic using this preemptive treatment protocol.

Graft and patient survival

时间窗: 1 year

Study will assess the overall 1 year patient and graft survival.

次要结局

未报告次要终点

研究者

发起方

Mayo Clinic

申办方类型

Other

责任方

Principal Investigator

主要研究者

Bashar Aqel

Principal Investigator

Mayo Clinic

研究点 (1)

Loading locations...

相似试验

招募中

不适用

Sequential Therapies Modeled on Evolutionary Dynamics for Breast CancerMetastatic Breast Cancer

NCT06409390H. Lee Moffitt Cancer Center and Research Institute15

Unknown

2 期

Rapid Antidepressant Effects of ATP and PhosphocreatineMajor Depressive Disorder

NCT03138681Zhujiang Hospital42

终止

4 期

Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained PatientsCigarette SmokingMethadone Maintenance

NCT02147132University of Cincinnati7

终止

3 期

Hyperthermia Treatment in Conjunction With Mitomycin C Versus Bacillus Calmette-Guérin Immunotherapy (BCG) for Superficial Bladder CancerUrinary Bladder DiseasesUrinary Bladder NeoplasmsUrinary Bladder CancerMalignant Tumor of Urinary BladderUrologic DiseasesUrologic NeoplasmsNeoplasmsNeoplasms by Site

NCT00384891Medical Enterprises Europe B.V.190

已完成

1 期

Trial to Evaluate the Safety and Immunogenicity of Priming Regimens of 426c.Mod.Core-C4b and Optional Boost Regimen With HIV Trimer BG505 SOSIP.GT1.1 gp140, Both Adjuvanted With 3M-052-AF + Alum in Healthy, Adult Participants Without HIVHIV-1-infection

NCT05471076National Institute of Allergy and Infectious Diseases (NIAID)52