Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
- Registration Number
- NCT05244694
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
- healthy adult men and women;
- 18-45 years of age;
- BMI 18-30 kg/m2;
- non-pregnant/non-breastfeeding;
- non-nicotine users;
Exclusion Criteria
- taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic functions
Self-reported history of:
- hepatic, renal, pulmonary, cardiovascular, or neurological disease;
- stroke or neurovascular disease;
- bleeding/clotting disorders;
- sleep apnea or other sleep disorders;
- diabetes;
- smoking;
- history of alcoholism or substance abuse, excessive alcohol consumption;
- hypertension;
- active cancer;
- autoimmune disease;
- immunosuppressant therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Insulin Insulin Participants will complete a 60 minute hyperinsulinemic-euglycemic infusion.
- Primary Outcome Measures
Name Time Method Amount of leg blood flow Change from baseline at minute 60 Measured with Doppler ultrasound (mL/min)
- Secondary Outcome Measures
Name Time Method Amount of cerebral blood flow Change from baseline at minute 60 Measured with trans-cranial Doppler ultrasound (cm/s)
Amount of muscle sympathetic nerve activity (MSNA) Change from baseline at minute 60 MSNA burst incidence (bursts/100 heart beats)
Trial Locations
- Locations (1)
University of Missouri
🇺🇸Columbia, Missouri, United States