"A comparitive study of efficacy of propofol with fentanyl and etomidate with fentanyl in attenuation of hemodynamic response and sequelae of laryngoscopy and endotracheal intubation in hypertensive patients"
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- to study the hemodynamic response during laryngoscopy and endotracheal intubation using inj propofol with inj fentanyl and inj etomidate with inj fentanyl in hypertensive patients
研究概览
简要总结
Laryngoscopy and endotracheal intubation during induction of general anaesthesia is associated with stress response which leads to hemodynamic changes that may be exaggerated in patients with hypertension and can have unfavourable outcomes.
The principle mechanism in hemodynamic changes during laryngoscopy and intubation are sympathetic stimulation , which results in increased heart rate and blood pressure which is usually transitory , variable and unpredictable . These hemodynamic responses are very well tolerated by healthy individuals but it can be hazardous to those with pre existing hypertension , coronary artery disease or cerebrovascular disease.
There are number of studies that have compared the efficacy of various induction agents, opioids, beta blockers , calcium channel blocker in obtundation of stress response and consequent hemodynamic effects during laryngoscopy and endotracheal intubation in nonhypertensive patients. But there is paucity of such studies in hypertensive patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.ASA physical status II 2.Patients with normal ( modified Mallampatti class I or II ).
排除标准
- •1.refusal by patients for the procedure 2.ASA physical status 3 and 4 3.uncontrolled hypertension (>160/90mmhg) 4.patient with the history of hypersensitivity to inj propofol and inj etomidate 5.Anticipated difficult airway 6.patient with cardiovascular diseases other than hypertension, epilepsy, renal, hepatic disease 7.Brochial asthma and COPD 8.presence of known primary or secondary adrenal insufficiency or on steroid medication.
结局指标
主要结局
to study the hemodynamic response during laryngoscopy and endotracheal intubation using inj propofol with inj fentanyl and inj etomidate with inj fentanyl in hypertensive patients
时间窗: basal parameters , pre-induction,after-induction, 1min,2min,3min,5min after intubation
次要结局
- To study the adverse effects like pain on injection, myoclonus, nausea, vomiting, ST elevation(During and after intubation)