Effect of Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Respiratory Failure
- Sponsor
- Taipei Veterans General Hospital, Taiwan
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- The patients connecting or disconnecting to the ventilators affected the RSBI values but not their predictive accuracies.
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
Detailed Description
98 ready for weaning patients were included and divided into success (n=71) and failure (n=27) groups based upon their weaning outcome. Before weaning, the RSBI values were determined under the patients disconnecting from the ventilator (RA-no ventilator) and still connecting to the ventilator with 4 different settings (fraction of inspired oxygen (FiO2) 21 or 40% combined with continuous positive airway pressure (CPAP) 0 or 5 cm H2O). The patients were extubated after completing the weaning trials. Successful weaning was defined as patients free from the ventilator for over 48 hours.
Investigators
Eligibility Criteria
Inclusion Criteria
- •intubated medical patients with mechanically ventilated more than 48 hours
- •clinically ready for weaning
- •Glasgow coma scales were at least 8
- •their ventilator settings were: assist-controlled, pressure support (PS)or synchronized intermittent mandatory ventilation plus PS mode, FiO2 40% or less, positive end-expiratory pressure 5 cm H2O or less, and sensitivity setting on 1 L/min. Their arterial blood gases results were acceptable
Exclusion Criteria
- •having ongoing lung or neuromuscular disease and signs of increased intracranial pressure
Outcomes
Primary Outcomes
The patients connecting or disconnecting to the ventilators affected the RSBI values but not their predictive accuracies.
Time Frame: Before the patient processing weaning trials
Secondary Outcomes
- Changes in FiO2 and CPAP settings have no effect on RSBI values but ventilator methods with FiO2 21% have higher incidence of adverse reactions.(Before the patient processing weaning trials)