Compensatory Cognitive Training in Clinical High Risk Latino Youth
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Clinical High Risk
- Sponsor
- University of California, San Diego
- Enrollment
- 120
- Locations
- 2
- Primary Endpoint
- Neurocognition (Global Cognitive Index z score)
- Last Updated
- 5 years ago
Overview
Brief Summary
This is a randomized study to compare Compensatory Cognitive Training (CCT) versus Recreational Therapy (RT) in Latino clinical high risk individuals in the US and Mexico.
Study hypotheses: Compared to those who receive RT, study participants receiving CCT will show significant improvement in neurocognition, functional capacity, self-rated functioning and clinical measures.
Detailed Description
This is a 12 week randomized study to compare Compensatory Cognitive Training (CCT) versus Recreational Therapy (RT) in Latino clinical high risk individuals in the US and Mexico. Study participants will be measured 3 times, at baseline, 12 and 24 weeks on all outcome measures. Study hypothesis: Study participants receiving CCT will show significant improvement at 12 and 24 weeks compared to baseline in 1) Neurocognition using the Global Cognitive Index z score derived from the MATRICS neurocognitive domain scores, 2) Functional Capacity as assessed by the UCSD Performance-based Skills Assessment (UPSA/UPSA-Adolescent), 3) Self-Rated Functioning as measured by the Specific Level of Functioning Scale (SLoF) and 4) Clinical symptom ratings as measured by the Scale of Prodromal Symptoms (SOPS) total score when compared to subjects receiving RT training across study time.
Investigators
Kristin Cadenhead, M.D.
Professor
University of California, San Diego
Eligibility Criteria
Inclusion Criteria
- •Meet Clinical High Risk criteria
- •Be of Latino descent
- •Speak Spanish as their preferred language
Exclusion Criteria
- •Concomitant medical or neurological illness
- •Brain injury with loss of consciousness \> 30 minutes
- •Current substance abuse (excluding nicotine)
- •High suicidal risk
Outcomes
Primary Outcomes
Neurocognition (Global Cognitive Index z score)
Time Frame: 3 and 6 months post-baseline
The CGI is derived based on Z scores across multiple neurocognitive domains and is a representation of global cognition
Secondary Outcomes
- Functional capacity (UPSA/UPSA-A)(3 and 6 month post-baseline)